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Neural Connections Blog

MD Biosciences insights discussing preclinical research in Pain and Neurodegenerative Conditions

Increase Validity of Preclinical Pain Research

If you work in drug discovery and development, you are well aware of the failure rate at...

Preclinical Pig Models for Therapeutic Studies

Historically, rodent models have been used for the discovery of various biological mechanisms...

Behavior tests used with the 6-OHDA model of PD, and what they tell us.

6-OHDA lesioned rats exhibit a number of motor behavioral and non-motor impairments which have...

Preclinical Models for Diabetic Neuropathy

Diabetic neuropathies include a range of dysfunctions of the peripheral nerves that can be...

Cell Types Involved in ischemic Neuroinflammation

Post-stroke neuroinflammation is a very complex phenomenon involving multiple resident and...

Cognitive Impairment Neurodegenerative Disease Models

Diseases of the central nervous system are extremely debilitating, increasingly common, and...

Key features of the 6-OHDA model, their benefits and drawbacks

The 6-OHDA model has contributed significantly to our understanding of Parkinson’s Disease and...

Preclinical Pain Models. Translating to Clinic

Management of acute pain related to surgical intervention, termed postoperative pain, continues...