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Chemotherapy-induced Peripheral Neuropathy

Mimic peripheral neuropathy as a result of chemotherapy treatment.

 

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Preclinical efficacy models of Chemotherapy-induced Pain

 

Neurotoxicity and peripheral neuropathy are standard side effects of agents used for chemotherapy. Paclitaxel (taxol) is an antineoplastic agent used to treat a variety of cancers and vincristine is commonly used to treat leukemias and lymphomas. A side effect is peripheral neuropathy and is a limiting factor for dose levels required for anti-tumor effects. 

 

Models offered by MD Biosciences

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Pain response

MD Biosciences utilizes common pain tests to assess the level of neuropathic pain as a result of chemotherapy treatment. Data shows Von Frey force (g) in the taxol-induced chemotherapy neuropathy.

taxol-induced-neuropathic-pain-mdbiosciences

IENF Analysis

Intraepidermal nerve fiber analysis is a gold standard clinical tool in diagnosing neuropathies. MD Biosciences incorporates this clinically-relevant staining into our models of CIPN. Data shows IENF analysis in the cisplatin model of CIPN.

IENF Cisplatin-CIPN-mdbiosciences
 

READY TO DISCUSS YOUR PROGRAM?

If you are ready to discuss how a partnership can fit into your development program, our scientists are eager to explore the possibilities with you. Like many other pharmaceutical and medical device developers, you can rely on predictive preclinical data.

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