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Chemotherapy-induced Peripheral Neuropathy

Mimic peripheral neuropathy as a result of chemotherapy treatment.

 

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Preclinical efficacy models of Chemotherapy-induced Pain

 

Neurotoxicity and peripheral neuropathy are standard side effects of agents used for chemotherapy. Paclitaxel (taxol) is an antineoplastic agent used to treat a variety of cancers and vincristine is commonly used to treat leukemias and lymphomas. A side effect is peripheral neuropathy and is a limiting factor for dose levels required for anti-tumor effects. 

 

Models offered by MD Biosciences

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Assessments

MD Biosciences incorporates a range of in vivo measures and endpoint assessments that provide a robust data package enabling researchers to make critical decisions for their pipeline candidates. 

 
Pain behavioral anaysis

Behavior 

Pain behavior tests include dynamic weightbearing and Hargreaves to assess the distribution on each paw and sensitivity to heat.  
biomarker

Biomarkers

Evaluate pro-inflammatory and anti-inflammatory biomarkers from CSF samples. 
histology

Histology

IHC and histological staining to evaluate inflammatory markers in the paw skin. 

Scientific Data

MD Biosciences utilizes common pain tests to assess the level of neuropathic pain as a result of chemotherapy treatment. Data shows Von Frey force (g) in the taxol-induced chemotherapy neuropathy.

 

 
taxol-induced-neuropathic-pain-mdbiosciences
 
 
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CIPN datasheet

 

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READY TO DISCUSS YOUR PROGRAM?

If you are ready to discuss how a partnership can fit into your development program, our scientists are eager to explore the possibilities with you. Like many other pharmaceutical and medical device developers, you can rely on predictive preclinical data.

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