Stroke and Ischemia Models in Rodents

Focal and global ischemia models that replicate human injury

MD Biosciences provides well-characterized stroke models for translational stroke research, including MCAO stroke models in rodents (permanent and transient) and global ischemia models (4VO). These models closely replicate human ischemic injury, offering essential insights into neurodegeneration, neuroinflammation, and therapeutic efficacy. By leveraging these animal models of ischemic stroke, researchers can generate robust preclinical data to accelerate the development of effective stroke interventions.

MCAo Focal Ischemia (permanent and transient)

The focal cerebral ischemic model (MCAo) of stroke is a widely used model for assessing ischemic brain injury. By occluding the middle cerebral artery, this model reduces cerebral blood flow, affecting both the striatum and cortex, and mimicking focal brain damage observed in human stroke. Transient occlusion is where the artery is temporarily blocked before reperfusion while permanent occlusion causes extensive damage.
4VO Global Ischemia

The global ischemia model involves the permanent occlusion of vertebral arteries and the transient occlusion of carotid arteries, leading to brain injury in the hippocampus due to reduced cerebral blood flow. This model mimics conditions such as cardiac arrest and coronary bypass surgery, and is used to evaluate the effects of reduced blood flow to the brain. It also helps assess neurodegeneration, dementia, and oxidative stress.

Scientific Data

Diversity in Stroke Models

The figure shows grip test results in the MCAo stroke model, revealing significant differences between young and aged males, as well as between aged males and aged females.

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