Peripheral Nerve Repair Models in Pigs and Rodents

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Pig and rodent models for nerve repair devices and biologics

 MD Biosciences offers specialized rodent and translational pig models to advance nerve repair research. Pigs are a promising model for peripheral nerve repair studies due to their ability to mimic critical gaps and facilitate various functional assays, such as computerized gait analysis, compound motor action potential (cMAP) tests, and distal sensory nerve action potential (DSNAP) assessments. The sciatic nerve dissection model mimics peripheral nerve damage, providing a robust platform to evaluate nerve repair technologies, including wraps, conduits, fillers, grafts, and growth factor formulations.

MD Biosciences provides a multifaceted approach with clinically relevant assessments, including histology, immunohistochemistry (IHC), biomarker analysis, behavioral assessments, and in vivo electrophysiology.

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Scientific Data

Catwalk Analysis in Pig Tibial Nerve Repair Model

The figure shows the maximum vertical force exerted by pigs on each leg after peroneal dissection. A force ratio greater than 1 indicates greater force on the intact leg, with recovery observed six weeks post-implantation in tube-implanted pigs.

 

Assessments

MD Biosciences offers comprehensive in vivo measures and endpoint assessments, delivering robust data packages to support critical research decisions in the evolving landscape of drug development and biomedical research.

behavior

Behavior 

Conduct extensive pain, sensory, motor, and cognitive behavioral testing.

biomarker

Biomarkers

Explore inflammatory and pain biomarkers in disease-specific tissues.

histology

Histology

Characterize tissue and cellular changes in disease, pain, and neurodegeneration.

electrophysiology

Electrophysiology

Measure motor and sensory evoked potentials to assess disease progression and pain.

Plan a nerve repair study

Request a quote for a pig or rodent nerve repair study, or speak with a scientist about gap length, repair method and functional endpoints.

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