Multiple Sclerosis & Demyelinating Autoimmune/Neurological Disorders
Due to the clinical and pathological similarities of experimental autoimmune encephalomyelitis (EAE) and Multiple Sclerosis (MS), EAE is a model for the study of human demyelinating disease. Both EAE and MS are characterized by a relapsing-remitting disease course with subsequent progressive disability. EAE is characterized by chronic inflammatory demyelination of the central nervous system (CNS) and involves autoimmune CD4+ Th1 cells. These cells develop in the peripheral lymphoid organ and travel to the CNS causing an immune response. The development of T cells is controlled largely by the expression of various cytokines, as well as cellular adhesion molecules.
MD Biosciences is an experienced research partner with strength in designing pharmacology efficacy studies for Multiple Sclerosis (MS) demyelination disorders. Our scientists are experienced with rapidly validating models from literature, and can work with your study requirements. Contact a scientist to discuss your programs today and to learn how we can help accelerate your research.
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We offer electrophysiology recording and analysis services suited for MS/EAE models featuring the DANTEC Keypoint Focus tool.