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Experimental Autoimmune Encephalomyelitis (EAE)

For the study of Human Demyelinating Diseases


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EAE model for the study of Multiple Sclerosis (MS)


Due to the clinical and pathological similarities of experimental autoimmune encephalomyelitis (EAE) and Multiple Sclerosis (MS), EAE  is a model for the study of human demyelinating disease. Both EAE and MS are characterized by a relapsing-remitting disease course with subsequent progressive disability. EAE is characterized by chronic inflammatory demyelination of the central nervous system (CNS) and involves autoimmune CD4+ Th1 cells. These cells develop in the peripheral lymphoid organ and travel to the CNS causing an immune response. The development of T cells is controlled largely by the expression of various cytokines, as well as cellular adhesion molecules.


MD Biosciences is an experienced research partner with strength in designing pharmacology efficacy studies for Multiple Sclerosis (MS) demyelination disorders. Our studies aren't limited to body weight and clinical score. We bring translational insight by incorporating electrophysiology for the study of degenerative and neuroprotective effects of therapies. 

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EAE Models



MD Biosciences incorporates a range of in vivo measures and endpoint assessments that provide a robust data package that enable researchers to make critical decisions. 

Pain behavioral anaysis


Pain behavior tests assess the response to various pain stimuli.  



Evaluate pro-inflammatory and anti-inflammatory biomarkers from CSF samples. 



IHC and histological staining to evaluate inflammatory markers in the paw skin. 



Evaluate spontaneous nerve firing using in vivo electrophysiology.

Scientific Data

Electrophysiology (EP) unveils motor and sensory phenomenons in Neuroinflammatory Diseases such as MS/EAE. By adding electrophysiology to studies, we are able to detect changes in disease severity when clinical scores aren't sensitive enough to reflect changes, predict what may happen in the motor system prior to clinical scores showing changes, and understand the neuroprotective effects of therapeutics. 

electrophysiology in EAE
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EAE datasheet


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If you are ready to discuss how a partnership can benefit your development program, our scientists are eager to explore the possibilities with you. Like many other pharmaceutical and medical device developers, you can rely on predictive preclinical data.  

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