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Experimental Autoimmune Encephalomyelitis (EAE)

For the study of Human Demyelinating Diseases

 

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Multiple Sclerosis

 

Due to the clinical and pathological similarities of experimental autoimmune encephalomyelitis (EAE) and Multiple Sclerosis (MS), EAE  is a model for the study of human demyelinating disease. Both EAE and MS are characterized by a relapsing-remitting disease course with subsequent progressive disability. EAE is characterized by chronic inflammatory demyelination of the central nervous system (CNS) and involves autoimmune CD4+ Th1 cells. These cells develop in the peripheral lymphoid organ and travel to the CNS causing an immune response. The development of T cells is controlled largely by the expression of various cytokines, as well as cellular adhesion molecules.

 

MD Biosciences is an experienced research partner with strength in designing pharmacology efficacy studies for Multiple Sclerosis (MS) demyelination disorders. Our studies aren't limited to body weight and clinical score. We bring translational insight by incorporating electrophysiology for the study of degenerative and neuroprotective effects of therapies. 

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EAE Models

Model
Species
Rat

Going Beyond Clinical Scores

Electrophysiology (EP) unveils motor and sensory phenomenons in Neuroinflammatory Diseases such as MS/EAE. By adding electrophysiology to studies, we are able to detect changes in disease severity when clinical scores aren't sensitive enough to reflect changes, predict what may happen in the motor system prior to clinical scores showing changes, and understand the neuroprotective effects of therapeutics. 

 

Motor action potential-MOG EAE
 

READY TO DISCUSS YOUR PROGRAM?

If you are ready to discuss how a partnership can benefit your development program, our scientists are eager to explore the possibilities with you. Like many other pharmaceutical and medical device developers, you can rely on predictive preclinical data.  



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