MD Biosciences leverages cutting-edge experimental autoimmune encephalomyelitis (EAE) models to explore demyelinating diseases similar to Multiple Sclerosis (MS). Our EAE models replicate the relapsing-remitting pattern and progressive disability of MS. We integrate behavior analysis, biomarker analysis, and histology into our studies and go further with advanced electrophysiology to deliver a comprehensive view of how therapies impact neurodegeneration and promote neuroprotection. Discover deeper insights into therapeutic efficacy with our expert approach.
EAE Models:
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MOG-EAE Model
The myelin oligodendrocyte glycoprotein (MOG)-induced EAE model is used to examine inflammatory diseases of the CNS and resembles many aspects of human Multiple Sclerosis (MS).
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PLP-EAE Model
The proteolipid protein (PLP)-induced EAE model is designed to study remitting and relapsing forms of demyelinating disease. PLP is a key protein component of myelin and can trigger encephalitis in specific mouse strains.
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MBP-EAE Model
When conducting MS research, administration of one dose of MBP in a Lewis rat leads to a single relapse that is characterized by hind paw paralysis. This can be characterized histologically, by infiltration of mononuclear cells to the cervical spinal cord and formation of foci. This model is self-limiting and does not show demyelination.
Scientific Data
Electrophysiology (EP) unveils motor and sensory phenomenons in Neuroinflammatory Diseases such as MS/EAE. By adding electrophysiology to studies, we are able to detect changes in disease severity when clinical scores aren't sensitive enough to reflect changes, predict what may happen in the motor system prior to clinical scores showing changes, and understand the neuroprotective effects of therapeutics.
EAE Datasheet
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