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Neural Connections Blog

MD Biosciences insights discussing preclinical research in Pain and Neurodegenerative Conditions

Why are potential pain therapies getting lost in translation?

It is estimated that 1.5 billion people worldwide suffer from Chronic pain. While research has seen tremendous advances in our understanding of pain and neurobiology over the last 20 years, there is still a lack of newly approved treatments. There have been many notable failures despite preclinical data supporting the mechanism of compounds with drug-like properties and good safety profiles. So why are these potential therapies getting lost in translation? 

Monitoring pain in EAE animals experiencing paralysis

Many neurodegenerative diseases such as Multiple Sclerosis, ALS, and Rhett Syndrome involve...

3 ways to improve clinical relevance of preclinical CNS data

The success rate from first candidate to market launch is less than 1%, requiring approximately...

Pain Studies In Pig: advantages for nerve blocks, local & systemic therapies

MD Biosciences lab has an exclusive expertise in pain studies in the pig. Our scientists have...

Weekly Science Blog: Possible Therapies for Spinal Cord Injuries, Reversal for Inflammatory Diseases and More!

It's Tuesday, which means MD Biosciences is providing coverage of the latest fascinating and...

MDB Neuropathic Pain Porcine Model Publication Featured in Neurobiology of Pain Journal

MDB Scientists recently published a paper titled “Human-like cutaneous neuropathologies...

Behavioral Research Assessments & Applications: Quantify Cognitive, Emotional, Sensory & Motor Functions

Neurological diseases often result in a combination of motor and cognitive deficits. Thus,...

Glatiramer Acetate (Copaxone® Generics) and Batch Release Testing in MS/EAE at MD Biosciences

 

MDB Gains OECD-GLP certification for In Vivo Glatiramer Acetate Batch Release Testing Services

Why the Pig is a Good Preclinical Model for Wound Healing

There are many options for preclinical wound healing research. All studies are designed to predict...

Pain Response in Pigs Mimics Human Pain Behavior

The pig peripheral neuritis trauma (PNT) model is an important transitional model that bridges...