From Acute to Chronic: Where the 2026 Sodium Channel Programs Are Headed
As of August 2026, acute post-surgical pain has an approved non-opioid sodium channel blocker and a second program with published Phase 2b data....
Peripheral Nerve Repair: What the Regeneration Endpoints Actually Tell You
Peripheral nerve repair occupies an unusual position in translational neuroscience. The biology is more permissive than in the central nervous...
Osteoarthritis Pain Models: Choosing the Species Before You Choose the Endpoint
Osteoarthritis is one of the largest unmet needs in pain, and one of the most stubborn translational problems in the field. The patient population is...
Electrophysiology as a Translational Endpoint: Why Nerve Conduction Belongs in More Preclinical Packages
Most preclinical neuroscience programs are still built around two categories of evidence. Behavior tells you what the animal does, and histology...
Quantitative Histology: What Computational Image Analysis Adds to a Preclinical Package
Histology has always carried a quiet tension. It is the most direct evidence a preclinical study can offer, a look at the actual tissue the candidate...
The Cuprizone Model: Reading Demyelination and Remyelination Without the Autoimmune Noise
Remyelination has become the most interesting frontier in multiple sclerosis. The approved therapies for relapsing disease are effective at...
What AAALAC Accreditation Actually Signals to Partners
AAALAC accreditation carries practical weight in preclinical drug development, and its implications for program quality extend beyond the credential...
BoNT in Postsurgical Pain: Mechanistic and Behavioral Findings from a Porcine SMIR Model
Botulinum toxin type A has been established as a therapeutic agent in spasticity, dystonia, and cosmetic indications for several decades. Its...
Adult Tissue and Sex Diversity in SCI: Translational Drug Development
Spinal cord injury presents one of the most challenging translational profiles in central nervous system drug development. The clinical need is...