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Neural Connections Blog

MD Biosciences insights discussing preclinical research in Pain and Neurodegenerative Conditions

Preclinical Efficacy Models of Chemotherapy-Induced Peripheral Neuropathy

Chemotherapeutics like taxol, vincristine, cisplatin, and oxaliplatin are commonly used to treat cancer, but come with side effects such as neurotoxicity and peripheral neuropathy, which significantly impact the quality of life of cancer patients. One of the most severe complications is the onset of acute or chronic neuropathic pain experienced by approximately 60% of patients. Symptoms can range from minor tingling to severe paralysis, profoundly impacting daily life. These symptoms become a barrier to achieving effective anti-tumor doses, since chemotherapy may be halted or reduced. Therefore, CIPN models are crucial for advancing cancer treatment outcomes and alleviating patient suffering.

Promoting Diversity for Translational Success

In preclinical efficacy studies, several factors are often overlooked, and it is important to...

In Vitro Modeling

The goal of the preclinical development process is to help predict clinical efficacy, emphasizing...

Wound Healing Models in Pigs

It is important to bridge the gap between lab findings and clinical applications using...

Advancing Nerve Injury and Repair Models

Understanding Mechanisms Underlying Neuropathic Pain

Porcine Translational Research

Advancing Beyond Rodent and Non-Human Primate Models

While rodent models have contributed...