electrophysiology: an in vivo biomarker for neurology models
Animal models are commonly used in preclinical development to mimic human disease and response. Over the past several decades, drug developers have increased their focus on biomarkers that can indicate changes in the underlying mechanisms and biological pathways. When neurological conditions and pain are involved, neuronal networks are affected making some traditional biomarkers less relevant. Electrophysiology (EP), an in vivo biomarker, provides the ability to study neurological dysfunctions, how the nervous system is affected, and how it responds to various treatments.