Why are potential pain therapies getting lost in translation?
It is estimated that 1.5 billion people worldwide suffer from Chronic pain. While research has seen tremendous advances in our understanding of pain and neurobiology over the last 20 years, there is still a lack of newly approved treatments. There have been many notable failures despite preclinical data supporting the mechanism of compounds with drug-like properties and good safety profiles. So why are these potential therapies getting lost in translation?