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Neural Connections Blog

MD Biosciences insights discussing preclinical research in Pain and Neurodegenerative Conditions

Three ways to approach translation

As the general population continues to age, the economic burden of chronic pain and neurodegenerative diseases is increasing and becoming unsustainable. Unfortunately, the pipeline of new therapeutics has thinned over the past several years due to several clinical stage failures. Reasons for these failures may include insufficient understanding of neurobiological mechanisms, poor translation of preclinical data, clinical trial challenges, and the complexity and variability of the human brain and neurological diseases.

electrophysiology: an in vivo biomarker for neurology models

Animal models are commonly used in preclinical development to mimic human disease and response....

Preclinical Human Pain Models. Translating to Clinic

Management of acute pain related to surgical intervention, termed postoperative pain, continues to...

A minipig Model of Incisional pain

The use of animal models for the research of post-operative pain (POP) has been well described[1]....

Do clinical scores tell us all we need to know?

Multiple sclerosis is a disease in which the immune system attacks the myelin sheath that covers...

Assessing and measuring pain behaviors in preclinical studies

Pain plays an important role in human life acting as a defense mechanism that protects us from...

What electrophysiology brings to preclinical studies

Neurons communicate with each other as well as other muscles and organs through electrical events...

Why are potential pain therapies getting lost in translation?

It is estimated that 1.5 billion people worldwide suffer from Chronic pain. While research has seen...

Monitoring pain in EAE animals experiencing paralysis

Many neurodegenerative diseases such as Multiple Sclerosis, ALS, and Rhett Syndrome involve...