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Neural Connections Blog

MD Biosciences insights discussing preclinical research in Pain and Neurodegenerative Conditions

The effect of the housing environment and handling on behavior assays

An excerpt from MD Biosciences publication in the Autumn 2022 issue of Göttingen Minipigs Magazine. 

 

MD Biosciences operates a neuroscience research facility that was purpose-built for translational research and includes dedicated wings for in vitro and biomarker assays, rodent and translational pig research. Since the opening of the research facility in 2021, we have been monitored the effect of this purpose-built facility on behavior assays and compared it to data from standard housing facilities. Findings are ongoing, however an intermediate finding of results has been published.

electrophysiology: an in vivo biomarker for neurology models

Animal models are commonly used in preclinical development to mimic human disease and response....

A minipig Model of Incisional pain

The use of animal models for the research of post-operative pain (POP) has been well described[1]....

Do clinical scores tell us all we need to know?

Multiple sclerosis is a disease in which the immune system attacks the myelin sheath that covers...

Assessing and measuring pain behaviors in preclinical studies

Pain plays an important role in human life acting as a defense mechanism that protects us from...

What electrophysiology brings to preclinical studies

Neurons communicate with each other as well as other muscles and organs through electrical events...

Why are potential pain therapies getting lost in translation?

It is estimated that 1.5 billion people worldwide suffer from Chronic pain. While research has seen...

Monitoring pain in EAE animals experiencing paralysis

Many neurodegenerative diseases such as Multiple Sclerosis, ALS, and Rhett Syndrome involve...

3 ways to improve clinical relevance of preclinical CNS data

The success rate from first candidate to market launch is less than 1%, requiring approximately 22...

Pain Studies In Pig: advantages for nerve blocks, local & systemic therapies

MD Biosciences lab has an exclusive expertise in pain studies in the pig. Our scientists have...

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