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The latest developments in preclinical research models. 

Insights on increasing the translational value of your preclinical development program. 

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4 min read

Cuprizone and EAE Models of Demyelination: Mechanism and Application

Multiple sclerosis therapy has been transformed by agents that control inflammation, and the unmet need has shifted...

4 min read

Non-Opioid Analgesic Mechanisms and Their Preclinical Pain Models

The FDA issued draft guidance on the development of non-opioid analgesics for acute pain in 2022, covering development...

4 min read

Diabetic Wound Healing in the GLP-1 Era: What Systemic Metabolic Control Does Not Solve

The GLP-1 receptor agonists have changed the trajectory of type 2 diabetes care, and the evidence now suggests their...

4 min read

Five Days From a Single Injection: What Long-Acting Local Anesthetics Have to Prove in the Pig

Postoperative pain management is in the middle of a reimbursement shift. Since January 2025, Medicare has paid...

4 min read

Preclinical Models of Diabetic Neuropathy: STZ, High Fat Diet, and the ZDF Rat

Diabetic peripheral neuropathy affects nearly half of people living with diabetes, and it remains one of the harder...