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Peripheral Nerve Injury 

Preclinical models for assessing neuropathic pain as a result of injury to the nerve.

Understanding Mechanisms underlying Neuropathic Pain


Neuropathic pain may arise from many different disease states and present with a variety of symptoms, including shooting or burning pain, tingling, numbness, and allodynia (pain in response to a normally innocuous stimulus). Clinically significant relief is often difficult to achieve, in part because conventional opioid therapy is typically less effective for neuropathic pain. Also, patients vary widely in their response to other types of analgesics. Understanding the mechanisms underlying neuropathic pain syndromes is crucial to the development of more effective therapies.


Models of Peripheral Nerve Injury

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Neurological disorders often result in a combination of motor and cognitive deficits. Thus, behavioral assessments in conjunction with physiological readouts offer a broader understanding of the basic biological mechanism of disease and cognitive impairment, highly relevant to therapeutic developments. 

Pain behavioral anaysis


Pain behavior tests assess the response to various pain stimuli.  



Evaluate pro-inflammatory and anti-inflammatory biomarkers from CSF samples. 



IHC and histological staining to evaluate inflammatory markers in the paw skin. 



Evaluate spontaneous nerve firing using in vivo electrophysiology.

Scientific Data

Data shows dynamic weight bearing in the CCI model.  

Dynamic weight bearing_CCI model_MD Biosciences
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Nerve injury datasheet (1)


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If you are ready to discuss how a partnership can fit into your development program, our scientists are eager to explore the possibilities with you. Like many other pharmaceutical and medical device developers, you can rely on predictive preclinical data.

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