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Peripheral Nerve Injury 

Preclinical models for assessing neuropathic pain as a result of injury to the nerve.

Understanding Mechanisms underlying Neuropathic Pain

 

Neuropathic pain may arise from many different disease states and present with a variety of symptoms, including shooting or burning pain, tingling, numbness, and allodynia (pain in response to a normally innocuous stimulus). Clinically significant relief is often difficult to achieve, in part because conventional opioid therapy is typically less effective for neuropathic pain. Also, patients vary widely in their response to other types of analgesics. Understanding the mechanisms underlying neuropathic pain syndromes is crucial to the development of more effective therapies.

 

Models of Peripheral Nerve Injury

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IENF Staining

Intraepidermal nerve fiber (IENF) analysis in skin biopsy samples has become a standard clinical tool in diagnosing neuropathies in patients. Focused on using clinically relevant assessments in preclinical studies, MD Biosciences offers IENF analysis in its studies. Data shows IENF staining in the pig model of peripheral neuropathy.

PNT sciatic nerve injury pig skin biomarker

Pain Response

Neurological disorders often result in a combination of motor and cognitive deficits. Thus, behavioral assessments in conjunction with physiological readouts offer a broader understanding of the basic biological mechanism of disease and cognitive impairment, highly relevant to therapeutic developments. Data shows Von Frey and Cold Plate tests in the CCI model in rats. 

CCI model in rats
 

READY TO DISCUSS YOUR PROGRAM?

If you are ready to discuss how a partnership can fit into your development program, our scientists are eager to explore the possibilities with you. Like many other pharmaceutical and medical device developers, you can rely on predictive preclinical data.

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