Peripheral Nerve Injury
Preclinical models for assessing neuropathic pain as a result of injury to the nerve.
Understanding Mechanisms underlying Neuropathic Pain
Neuropathic pain may arise from many different disease states and present with a variety of symptoms, including shooting or burning pain, tingling, numbness, and allodynia (pain in response to a normally innocuous stimulus). Clinically significant relief is often difficult to achieve, in part because conventional opioid therapy is typically less effective for neuropathic pain. Also, patients vary widely in their response to other types of analgesics. Understanding the mechanisms underlying neuropathic pain syndromes is crucial to the development of more effective therapies.
Models of Peripheral Nerve Injury
Intraepidermal nerve fiber (IENF) analysis in skin biopsy samples has become a standard clinical tool in diagnosing neuropathies in patients. Focused on using clinically relevant assessments in preclinical studies, MD Biosciences offers IENF analysis in its studies. Data shows IENF staining in the pig model of peripheral neuropathy.
Neurological disorders often result in a combination of motor and cognitive deficits. Thus, behavioral assessments in conjunction with physiological readouts offer a broader understanding of the basic biological mechanism of disease and cognitive impairment, highly relevant to therapeutic developments. Data shows Von Frey and Cold Plate tests in the CCI model in rats.