Parkinson’s Disease Models in Rats and Mice | 6-OHDA and MPTP

Two toxin models of Parkinson’s disease and an in vitro screen

MD Biosciences runs the 6-OHDA rat model and the acute MPTP mouse model of Parkinson’s disease, with motor behavior, tyrosine hydroxylase (TH) histology and biomarker readouts in one data package. An in vitro alpha synuclein neurodegeneration assay screens compounds before in vivo work. Study designs are customizable.

6-OHDA Parkinson's Rat Model

The 6-hydroxydopamine (6-OHDA) Parkinson's rat model is a unilateral lesion model used to study damage to the Nigrostriatal pathway. 6-OHDA is delivered via stereotaxic injection into brain regions like the substantia nigra (SN), ventral tegmental area (VTA), or striatum, bypassing the blood-brain barrier to induce dopaminergic degeneration characteristic of Parkinson’s disease.

Download the Parkinson's disease datasheet.
Acute MPTP Parkinson's Mouse Model
In Vitro Neurodegeneration Screening Assay (alpha-synuclein)

Scientific Data

Endpoint Analysis in MPTP

The figure shows reduced TH staining in the SNpc in the MPTP rodent model, indicating dopaminergic neuron loss in the disease model.

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Immunohistochemical staining for Tyrosine Hydroxylase in SNpc

Behavior

Conduct extensive pain, sensory, motor, and cognitive behavioral testing.

Biomarkers

Explore inflammatory and pain biomarkers in disease-specific tissues.

Histology

Characterize tissue and cellular changes in disease, pain, and neurodegeneration.