Cortical Trauma Model in Rats

SPEAK WITH A SCIENTIST

mdbiosciences-neurology-leading-preclinical-CRO-1

A focal, reproducible model of brain injury

The cortical trauma injury (CTI) model produces a focal, reproducible brain injury by localized removal of cortical tissue in rats. MD Biosciences uses it to evaluate neuroprotective and regenerative therapies, measuring lesion histology, sensorimotor and cognitive recovery, and neuroinflammation biomarkers over a customizable study period. Because the lesion is controlled and low in variability, the model suits local delivery and regenerative approaches that are difficult to assess in diffuse injury models.
REQUEST A STUDY QUOTE
Cortical Trauma rat-1
Scientific Data

Histology in Cortical Trauma Model

The figure shows HE staining of a rat brain 4 weeks after local cortex removal.

DOWNLOAD DATASHEET

Assessments

MD Biosciences offers comprehensive in vivo measures and endpoint assessments, delivering robust data packages to support critical research decisions in the evolving landscape of drug development and biomedical research.
behavior

Behavior 

Conduct extensive pain, sensory, motor, and cognitive behavioral testing.

biomarker

Biomarkers

Explore inflammatory and pain biomarkers in disease-specific tissues.

histology

Histology

Characterize tissue and cellular changes in disease, pain, and neurodegeneration.

Plan a cortical trauma study

Request a quote for a CTI study or speak with a scientist about endpoints and study length.

REQUEST A STUDY QUOTE
SPEAK WITH A SCIENTIST