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Preclinical Laboratory Services

Post-Operative Pain

Acute Pain in Rodents and Pigs

Post-Operative Pain Models

 

The under treatment of post-operative (incisional) pain has been recognized to delay patient recovery and discharge from hospital. Despite recognition of the importance of effective pain control, up to 70% of patients still complain of moderate to severe pain post operatively. The most commonly used model to test the effect of new analgesic drugs in post-operative (incisional) pain is the Brennan model. Although, this model can provide good answers to systemic drugs it is less suitable for testing local treatments such as implants, patches, medical devices and creams. 

 

MD Biosciences has developed a unique post-operative (incisional) model to meet this growing research need and allows for the assessment of local and systemic therapies. 

 

MD Biosciences offers both the rodent and a porcine model of POP. The porcine POP provides greater translational relevance for the evaluation of topical and local treatments. We have published the characterization of the model in the Eur J Pain (European Journal of Pain, Sept 2013, Characterization of a porcine model of post-operative pain, Dr Sigal Meilin, MD Biosciences)

 

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Assessments:
  • von Frey
  • Wound score (pigs)
  • Inflammation score (pigs)
  • Behavior Score (pigs)
  • Motor function (pigs)
  • Histology (pigs)
  • Gross pathology (pigs)
  • PK

            IHC Staining of Transverse Porcine Skin Sections Using PGP9.5 Antibody Demonstrating Peripheral Nerves

Screenshot 2019-06-24 09.35.11

von Frey in the pig POP model

latency time of tail flick nociceptive pain model

von Frey in the pig post-operative pain model. Pigs were dosed morphine and von Frey was evaluated compared to untreated pigs. 

 

MODELS AVAILABLE:

  • rat Brennan model
  • pig POP model

 

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