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Translational Model of Post-Operative Pain

Increasing the predictability of your preclinical studies by using models that are relevant to the clinical situation.


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Post-operative Pain in Pigs


Post-operative pain management is a major challenge for clinicians and patients. Unrelieved post-operative pain management causes patient suffering and discomfort, and can promote psychological and pathophysiological obstacles (Castel et al., 2014). While therapeutic agents and analgesic techniques are available, a large number of patients report moderate to severe pain following surgery. For this reason, it is essential to continue researching analgesic treatments for post-operative pain. 


Rodents have been the model of choice for the development of new treatments for acute pain, however, several limitations exist. Rodents are not useful for assessing topical and localized treatments, the anatomy of the skin differs from human skin, and healing occurs by wound contraction. Since pigs share similarities with human skin and heal by epidermal cell migration, MD Biosciences Neuro has characterized a porcine model for post-operative pain (POP) through skin incision and skin and muscle incision and retraction. 


Pig POP Study Design


Example Data

In a study, we aimed to evaluate the effect of Marcain and Exparel in the pig POP model. In additional to traditional pain assessments, we evaluate the locomotor activity of the animals. Data show open field post application in the pig POP model. 



Open Field Pig POP


If you are ready to discuss how translational studies can fit into your development program, our scientists are eager to explore the possibilities with you. Like many other pharmaceutical and medical device developers, you can rely on predictive preclinical data.  

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