Post Operative Pain Models in Rodents and Pigs

From the Brennan paw incision to a translational pig model

MD Biosciences runs two models of post operative pain (POP): the Brennan paw incision model in rodents and a translational pig model. The pig shares skin and neurological characteristics with humans, making it well suited to studying post surgical pain. Both models are assessed with histology, immunohistochemistry (IHC), biomarker analysis, behavioral testing and in vivo electrophysiology, and study designs are customizable.

Brennan Paw Incision Model in Rodents

The Brennan rodent model of paw incisional pain is a widely recognized and extensively validated tool for studying post-operative pain and evaluating analgesic treatments relevant to human conditions. A one cm incision is made through the skin, fascia, and muscle in the hind paw, replicating surgical tissue injury. This model delivers reliable results through behavioral and sensory assessments, essential for advancing postoperative pain research and therapy development.
Post-Operative Model in Pigs

Scientific Data

Open Field Assay in the Pig POP Model

The figure shows locomotor activity in the pig POP model at baseline and 2 hours post-treatment. Open field traces indicate a significant reduction in activity for both treatments compared to the vehicle group.

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