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Kidney Injury

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Advancing Preclinical Research with Kidney Injury Models 

Kidney injury (KI) models are commonly used to study renal dysfunction. Kidney injury can be induced through several methods, such as bilateral renal artery occlusion, nephrectomy of one kidney, and occlusion of the contralateral kidney. MD Biosciences developed a pig model for KI, leveraging the similarities pigs share with humans in organ function and drug response. Pig physiological characteristics, such as comparable kidney size and function, enhance the relevance of this model in assessing renal dysfunction and testing potential therapeutic interventions.
Blood biomarker levels AKI
Scientific Data

Blood Biomarkers in KI Pig Model

The figures show blood creatinine and urea concentrations following KI increase over time indicating declining kidney function.

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Assessments

MD Biosciences offers comprehensive in vivo measures and endpoint assessments, delivering robust data packages to support critical research decisions in the evolving landscape of drug development and biomedical research.
behavior

Behavior 

Conduct extensive pain, sensory, motor, and cognitive behavioral testing.

biomarker

Biomarkers

Explore inflammatory and pain biomarkers in disease-specific tissues.

histology

Histology

Characterize tissue and cellular changes in disease, pain, and neurodegeneration.

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MD Biosciences is your dedicated partner in drug development, offering tailored study designs, translational models, and comprehensive endpoints. With short lead times, competitive pricing, and deep scientific expertise, we help move your pipeline forward efficiently.

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