Kidney Injury

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Advancing Preclinical Research with Kidney Injury Models 

Kidney injury (KI) models are commonly used to study renal dysfunction. Injury can be induced through several methods, including bilateral renal ischemia/reperfusion and nephrectomy of one kidney followed by occlusion of the contralateral kidney. MD Biosciences offers acute kidney injury (AKI) models in both rodents and pigs, along with a chronic kidney disease (CKD) model in Göttingen minipigs, leveraging the similarities pigs share with humans in kidney size, organ function, and drug response. Together these models provide clinically relevant platforms for assessing renal dysfunction and testing therapeutic interventions across acute and chronic disease.
Blood biomarker levels AKI
Scientific Data

Blood Biomarkers in KI Pig Model

The figures show blood creatinine and urea concentrations following KI increase over time indicating declining kidney function.

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Assessments

MD Biosciences offers comprehensive in vivo measures and endpoint assessments, delivering robust data packages to support critical research decisions in the evolving landscape of drug development and biomedical research.
behavior

Behavior 

Conduct extensive pain, sensory, motor, and cognitive behavioral testing.

biomarker

Biomarkers

Explore inflammatory and pain biomarkers in disease-specific tissues.

histology

Histology

Characterize tissue and cellular changes in disease, pain, and neurodegeneration.

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MD Biosciences is your dedicated partner in drug development, offering tailored study designs, translational models, and comprehensive endpoints. With short lead times, competitive pricing, and deep scientific expertise, we help move your pipeline forward efficiently.

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