Acute Kidney Injury and Chronic Kidney Disease Models

AKI in pigs and rodents, CKD in Göttingen Minipigs

Kidney injury (KI) models are commonly used to study renal dysfunction. Injury can be induced through several methods, including bilateral renal ischemia/reperfusion and nephrectomy of one kidney followed by occlusion of the contralateral kidney. MD Biosciences offers acute kidney injury (AKI) models in both rodents and pigs, along with a chronic kidney disease (CKD) model in Göttingen minipigs, leveraging the similarities pigs share with humans in kidney size, organ function, and drug response. Together these models provide clinically relevant platforms for assessing renal dysfunction and testing therapeutic interventions across acute and chronic disease.