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Animal Models of Neuroma 

 

Models for studying why nerves fail to regenerate, leading to painful neuroma.

 

Neuroma results from hypercellular and proliferative outgrowth following a nerve injury, such as crush, stretch, or transection. In many cases, the blood-nerve barrier is disrupted leading to allodynia or an increased response of nerves and pain sensitization, causing a pain response from stimuli that doesn't normally provoke pain. 

 

Animal Models of Neuroma

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Assessments

Inflammatory biomarkers provide information related to mechanisms contributing to inflammatory pain and how well compounds modulate the inflammatory and/or pain response.
Pain behavioral anaysis

Behavior 

Pain behavior tests assess the response to various pain stimuli.  
biomarker

Biomarkers

Evaluate pro-inflammatory and anti-inflammatory biomarkers from samples. 
histology

Histology

Histological staining to evaluate changes to the nerve and spinal cell bundles. 
electrophysiology

Electrophysiology

Evaluate spontaneous nerve firing using in vivo electrophysiology.

Scientific Data

Histology from the Spared Nerve Injury model (SNI). Composite photo of a nerve (arrows on left) becoming a neuroma (boxed and shown below) which grows into the surrounding soft tissue.

Neuroma 3
 
 
Review the complete dataset.

Neuroma Datasheet image

 

Download datasheet
 

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If you are ready to discuss how a partnership can fit into your development program, our scientists are eager to explore the possibilities with you. Like many other pharmaceutical and medical device developers, you can rely on predictive preclinical data.

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