Neurodegenerative Disease Models
A multifaceted approach to assess neurological diseases.
Clinical Score
Clinical score is a hallmark assessment added to just about every disease model. Clinical score provides important information, but may not provide the whole story. MD Biosciences supplements clinical score data with additional assessments that provide insight into the mechanisms of neurodegenerative disease.
Data example from the MOG-EAE model.
Behavior Assessments
Neurological diseases often result in a combination of motor and cognitive deficits. Thus, behavioral assessments in conjunction with physiological readouts offer a broader understanding of the basic biological mechanism of disease and cognitive impairment, highly relevant to therapeutic developments.
Click here to learn about relevant behavior assessments.
Water maze data example from a Stroke ischemic model.
Enhancing our understanding of CNS Disorders
Electrophysiology enhances our understanding of neurological and pain indications. As one of the few laboratories in the world with these EP measurement capabilities, we can measure nerve regeneration, degeneration and protection in response to various treatments in non-clinical animal models.
Click here to learn more about electrophysiology capabilities
Electrophysiology data from the MOG-EAE model
IHC/Histology
Histological and biomarker assessments for neuronal changes and hallmarks of disease that can't be identified in standard clinical score or behavior measures.
Click here to learn more about our IHC/histology capabilities.
Example thionine staining of coronal brain sections.
READY TO DISCUSS YOUR PROGRAM?
If you are ready to discuss how a partnership can benefit your development program, our scientists are eager to explore the possibilities with you. Like many other pharmaceutical and medical device developers, you can rely on predictive preclinical data.
