STZ-Induced Diabetic Neuropathy Models

STZ-Induced Diabetic Neuropathy 

STZ is used to induce type I diabetes and diabetes-related complications, including diabetic peripheral neuropathy. There are multiple theories on the mechanism that involves peripheral neuropathy following STZ. Some of the mechanisms suggested are related to the hyperglycemic state of the rats suggesting that following the hyperglycemia, nerve endings are damaged either through an inflammatory process or interfering with blood supply. However, vast studies are also suggesting a mechanism of neuronal damage that occurs following STZ but it is unrelated to the hyperglycemic state of the animals.

These studies suggest direct damage to the nerves. For example, reactive oxygen species (ROS) mediate elevation of TRPV1 in neurons and the DRG is exposed to STZ in vitro. Therefore, the STZ model involves direct changes in the nerves that are not related to the inflammatory process. 

Model Specifications

• Readouts include: Blood glucose measurements, tactile/mechanical allodynia
• Endpoints: Histology and biomarker analysis (protein or mRNA) of sciatic nerve or paw skin)