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Diabetic Peripheral Neuropathy

Preclinical models for evaluating diabetes-induced neuropathic pain. 

 

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Understanding the pathophysiology of diabetic neuropathy

 

Neuropathic pain affects nearly 50% of people with diabetes, and our understanding of the pathophysiology remains incomplete contributing to a lack of therapeutics to treat the condition. MD Biosciences aims to provide efficacy studies with greater insight into the clinical condition by going beyond the standard assessments. Adding clinically relevant measures such as electrophysiology and IENF staining bring insight into the pathophysiology of these peripheral neuropathies. 

Diabetic Neuropathy Models

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Example Data

IENF Staining

IENF staining in plantar skin of rats from the STZ-induced diabetic neuropathy model. 

IENF STZ diabetic neuropathy

 

Electrophysiology Data

nSEP-induced withdrawal reflect in the HFD-induced peripheral neuropathy model. 

nSEP withdrawal reflex_HFD diabetic neuropathy

 

 

READY TO DISCUSS YOUR PROGRAM?

If you are ready to discuss how a partnership can fit into your development program, our scientists are eager to explore the possibilities with you. Like many other pharmaceutical and medical device developers, you can rely on predictive preclinical data.

 

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