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Wound Healing

Preclinical and Translational wound healing models for clinically relevant studies. 

 

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The Pig as a translational model for wound healing

MD Biosciences offers various models of wound healing in both rodents and pigs. Skin wound healing is a complex biological process activated by signaling pathways of epithelial and non-epithelial cells, which release a myriad of cytokines and growth factors. While rodent models provide data for earlier research stages, pig models are ideally suited for wound healing efficacy studies. Perhaps one of the most compelling arguments for use of pigs in wound healing studies is the similarity in the physiological processes through which pig and human heal. Pig and human close partial-thickness wounds primarily through re-epithelialization, rather than wound contraction as is the case with small animals such as rodents. Impaired wound healing can also be evaluated by using a diabetic animal. 

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Wound Healing Models offered

Assessments

Inflammatory biomarkers provide information related to mechanisms contributing to inflammatory pain and how well compounds modulate the inflammatory and/or pain response.

Wound Healing 

In life wound healing assessment over the course of the study.
biomarker

Biomarkers

Evaluate biomarkers from the skin. 
histology

Histology

IHC and histological staining to evaluate wound healing, new and mature collagen, nerve endings and blood vessels. 

Scientific Data

Figure 2. Wound area reduction (% relative to incision day (Day 0). Animals were examined on study days 1, 3, 7, 10 and 14. The closure of the incision was monitored, and wound area was compared to baseline at each time point

wound-healing-mdbiosciences
 
 
Review the complete dataset.

Wound Healing datasheet (1)

 

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READY TO DISCUSS YOUR PROGRAM?

If you are ready to discuss how a partnership can fit into your development program, our scientists are eager to explore the possibilities with you. Like many other pharmaceutical and medical device developers, you can rely on predictive preclinical data.

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