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Neural Connections Blog

 

5 min read

Psychiatry's New Mechanisms Arrived With Side Effects Attached

For seventy years, antipsychotics for schizophrenia acted on dopamine and antidepressants acted on monoamines. The...

4 min read

From Acute to Chronic: Where the 2026 Sodium Channel Programs Are Headed

As of August 2026, acute post-surgical pain has an approved non-opioid sodium channel blocker and a second program with...

4 min read

Peripheral Nerve Repair: What the Regeneration Endpoints Actually Tell You

Peripheral nerve repair occupies an unusual position in translational neuroscience. The biology is more permissive than...

3 min read

Osteoarthritis Pain Models: Choosing the Species Before You Choose the Endpoint

Osteoarthritis is one of the largest unmet needs in pain, and one of the most stubborn translational problems in the...

4 min read

Electrophysiology as a Translational Endpoint: Why Nerve Conduction Belongs in More Preclinical Packages

Most preclinical neuroscience programs are still built around two categories of evidence. Behavior tells you what the...