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Neural Connections Blog

 

3 min read

Pain Endpoints in Collagen-Induced and Antibody-Induced Arthritis

Pain is a principal presenting symptom of rheumatoid arthritis, and persistent pain despite low inflammatory activity...

4 min read

Preclinical Evidence Requirements for a Non-Opioid Analgesic

The clinical value of a non-opioid analgesic is defined relative to the established agents it is intended to replace,...

4 min read

Cuprizone and EAE Models of Demyelination: Mechanism and Application

Multiple sclerosis therapy has been transformed by agents that control inflammation, and the unmet need has shifted...

4 min read

Non-Opioid Analgesic Mechanisms and Their Preclinical Pain Models

The FDA issued draft guidance on the development of non-opioid analgesics for acute pain in 2022, covering development...

4 min read

Diabetic Wound Healing in the GLP-1 Era: What Systemic Metabolic Control Does Not Solve

The GLP-1 receptor agonists have changed the trajectory of type 2 diabetes care, and the evidence now suggests their...