Spinal Cord Injury
Evaluating neuro-regenerative and neuroprotective therapies.
Spinal cord injury (SCI) often results in sensory problems, severe motor dysfunction (such as complete paralysis) and chronic pain, making spinal cord injury research complex and challenging. Several preclinical models are commonly used to evaluate pain and motor dysfunction mechanisms associated with SCI.
Spinal Cord Injury Models
Contusion Injury in Rats
Cutting Injury in Rats
Extraction Injury in Rats
Basso Beattie and Bresnahan (BBB) score
Open field assay
Walking Gait (catwalk)
In vivo electrophysiology
Spinal cord histology
Spinal Cord Injury in a dish - Primary cells are dissociated directly from adult (>5 weeks old) rat spinal cord tissue, plated in media and incubated with test items or controls.
Cells are also monitored longitudinally, stained using immunocytochemistry against cytoskeletal antigens (Tubulin III) and neurites are quantified for length.
MD Biosciences incorporates a range of in vivo measures and endpoint assessments that provide a robust data package that enable researchers to make critical decisions.
Histology of Myelin Basic Protein (MBP) Immunoreactive Cells in the rat SCI model.
Synapse formation after spinal cord injury in a dish.