Acute Inflammatory Pain
Pain associated with tissue injury
Acute Inflammatory pain is commonly associated with tissue injury and it manifests itself as an expression of neuronal plasticity consisting of central and peripheral sensitization. Tissue injury causes a release of inflammatory mediators from damaged cells which become central to the initiation of the inflammatory cascade.
MD Biosciences offers acute inflammatory pain models that can be extended to evaluate a more chronic inflammatory pain state. We can help you study the release of cytokines and their role in the initiation and maintenance of the inflammatory response along with prostaglandins. Prostaglandins contribute to pain by direct activation of nociceptors and sensitization of primary afferent neurons to bradykinin and other mediators.