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Arthritic Inflammatory Pain

Joint Pain Associated with Osteoarthritis

 

Osteoarthritis (OA) is a common joint disease which can elicit chronic disabling pain in patients. OA is a degenerative condition involving chondrocyte death and cartilage erosion affecting the entire joint structure.
 
At MD Biosciences, we offer the monosodium iodoacetate (MIA) model for OA pain, which contains both an inflammatory and neuropathic pain component.

Models offered: 

  • MIA-induced OA in rats
  • MIA-induced joint inflammation in pigs

Assessments
Pain behavioral anaysis

Behavior 

Pain behavior tests include dynamic open field, weight bearing or limp score, hyperalgesia and others dependent on species.
biomarker

Biomarkers

Evaluate pro-inflammatory and anti-inflammatory biomarkers from CSF samples. 
histology

Histology

IHC and histological staining to evaluate inflammatory markers in the paw skin. 

Scientific Data

Response to von Frey in the rat MIA-induced OA model. Positive controls have an increased withdrawal 14 days after treatment. 

MIA_Von Frey_rats
 
 
Review the complete dataset.

MIA Datasheet

 

Download datasheet
 

READY TO DISCUSS YOUR PROGRAM?

If you are ready to discuss how a partnership can fit into your development program, our scientists are eager to explore the possibilities with you. Like many other pharmaceutical and medical device developers, you can rely on predictive preclinical data.

Request Proposal