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Neuroscience Laboratory Services

Arthritic Pain

Joint Disease | Arthritis | Pain Models

Joint Pain Associated with Rheumatoid Arthritis & Osteoarthritis

Rheumatoid Arthritis (RA) and Osteoarthritis (OA) are both common joint disease which can elicit chronic disabling pain in patients. RA is distinguished by inflammation and synovitis leading to joint destruction, whereas OA is a degenerative condition involving chondrocyte death and cartilage erosion affecting the entire joint structure.
At MD Biosciences, we offer pain models to assess joint pain conditions including both CFA and CIA models, standard models for RA. The monosodium iodoacetate (MIA) model for OA pain contains both an inflammatory and neuropathic pain component.

Assessments for Joint Pain:

  • Weight bearing
  • Thermal Hyperalgesia
  • Mechanical Allodynia
  • Paw edema
  • Open Field
  • Rotorod
  • Joint compression
  • Xray
  • Biomarkers
  • Histology 

Our scientists are experienced with rapidly validating models from literature, and can work with your study requirements. Contact us to discuss your programs today and to learn how we can help accelerate your research.


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  • Mouse CIA
  • Rat CIA
  • Rat MIA
  • Rat Polyarthritic
  • Rat Monoarthritic
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Fax: (651) 641 1773