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Neural Connections Blog

MD Biosciences insights discussing preclinical research in Pain and Neurodegenerative Conditions

Inflammatory Mediators & Neuropathic Pain Models

Neuropathic pain is a chronic pain condition caused by lesion or inflammation affecting the...

Pain & Inflammation Link | Need For Relevant Preclinical Models

Considering the close link between inflammation and the pain process, preclinical efficacy...

EAE Preclinical Model Associated With FDA Approved MS Drugs

The Experimental Autoimmune Encephalomyelitis (EAE) model is associated with FDA Approved MS...

What PD in Vivo Models Revealed About Pathogenesis & Treatment

Parkinson’s Disease (PD) is typically an adult-onset progressive neurodegenerative movement...

EAE Models for Evaluating Neuroprotective Treatment

Cognitive impairment is common in multiple sclerosis (MS), occuring at all stages of disease....

Why Post-operative Pain Is Under-Treated

Adequate pain relief following surgical procedures is well-documented to improve the degree and...

Pain Processing: Cation Channel Blockers. Choosing Pain Models

Sodium and calcium cation channel blockers.

Cannabinoid System | A Target For Pain Relief

The body's cannabinoid system consists of two cannabinoid receptors, CB1 and CB2, their endogenous...

α2-adrenergic Agonists & Tricyclic Antidepressants | Pain Model

α2-adrenergic receptors (α2ARs) are found in many areas in throughout the nervous system, but...