The Critical Role of Clinical Relevance in Effective Study Design
Enhancing clinical relevance in early-stage studies can improve efficiency, reduce costs, and guide critical decisions, ultimately advancing more CNS...
New Developments: Innovative Cold Pain Testing Methods
Cold testing in rats serves as a crucial tool in pain research, particularly in studying neuropathic pain and assessing the effectiveness of drugs....
Models of Acute Inflammatory Pain
Acute inflammatory pain is commonly associated with tissue injury and is characterized by neuronal plasticity involving both central and peripheral...
Advancing Parkinson’s Research: Insights from Diverse Disease Models
Parkinson’s Disease (PD) is a progressive neurodegenerative movement disorder that affects millions of people worldwide. PD is characterized by the...
The Development of Peripheral Nerve Repair Models
Nerve damage refers to injury or impairment to the nervous system. This can lead to loss of sensation, pain, or total paralysis. Nerve repair...
Inflammatory Biomarker Detection Increases Value in Early Drug Development
Inflammation is a key pathological driver in many neurological diseases. The interplay between the central and peripheral nervous systems and the...
Preclinical Efficacy Models of Chemotherapy-Induced Peripheral Neuropathy
Chemotherapeutics agents are commonly used to treat cancer, but come with side effects such as neurotoxicity and peripheral neuropathy, which...
Promoting Diversity for Translational Success
In preclinical efficacy studies, several factors are often overlooked, and it is important to evaluate variables like sex, age, species,...