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Chronic Post-Ischemia Pain (CPIP)

A preclinical model for Complex regional pain syndrome (CRPS)


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A novel preclinical animal model of complex regional pain syndrome-type I (CRPS-1)


Complex regional pain syndrome (CRPS) is a chronic pain condition often involving
hyperalgesia and allodynia of the extremities. CRPS is divided into CRPS-I and CRPS-II.
Type I occurs when there is no confirmed nerve injury. Type II is when there is known
associated nerve injury. Neuropathic inflammation, specifically activation of peripheral
nociceptors of C-fibers, has been shown to play a critical role in developing CRPS.

One of the models for CRPS is Chronic Post-Ischemia Pain Model (Hu et al., JOVE 155 (e60562): 1-6; 2020.


Study Design

Neuropathic pain-like syndrome is induced in rats by prolonged hindpaw ischemia and reperfusion. 

  • Rats
  • Hindlimb ischemia using an o-ring
  • 95-98% reduction in blood flow during ischemia period
  • Model length: up to 14 days
  • Positive controls: Morphine
  • Readouts: tactile allodynia (Von Frey), paw thickness


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Von Frey

Effects of morphine on Von Frey in the CPIP model.

CPIP model_Von Frey

Paw Thickness

The effect of morphine on paw thickness in the CPIP model. 

CPIP_paw thickness


If you are ready to discuss how a partnership can fit into your development program, our scientists are eager to explore the possibilities with you. Like many other pharmaceutical and medical device developers, you can rely on predictive preclinical data.

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