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Chronic Post-Ischemia Pain (CPIP)

A preclinical model for Complex regional pain syndrome (CRPS). 

 

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A novel preclinical animal model of complex regional pain syndrome-type I (CRPS-1)

 

Complex regional pain syndrome (CRPS) is a chronic pain condition often involving
hyperalgesia and allodynia of the extremities. CRPS is divided into CRPS-I and CRPS-II.
Type I occurs when there is no confirmed nerve injury. Type II is when there is known
associated nerve injury. Neuropathic inflammation, specifically activation of peripheral
nociceptors of C-fibers, has been shown to play a critical role in developing CRPS.

One of the models for CRPS is Chronic Post-Ischemia Pain Model (Hu et al., JOVE 155 (e60562): 1-6; 2020.

 

Study Design

Neuropathic pain-like syndrome is induced in rats by prolonged hindpaw ischemia and reperfusion. 

  • Rats
  • Hindlimb ischemia using an o-ring
  • 95-98% reduction in blood flow during ischemia period
  • Model length: up to 14 days
  • Positive controls: Morphine
  • Readouts: tactile allodynia (Von Frey), paw thickness

 

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Von Frey

Effects of morphine on Von Frey in the CPIP model.

CPIP model_Von Frey

Paw Thickness

The effect of morphine on paw thickness in the CPIP model. 

CPIP_paw thickness
 

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