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Neural Connections Blog

 

3 min read

CIPN Keeps Failing in the Clinic. The Preclinical Package May Be Why.

Chemotherapy induced peripheral neuropathy remains one of the most underserved symptoms in oncology supportive care....

3 min read

The Diabetic Wound Healing Model That Keeps Earning Its Keep

Chronic wounds in diabetic patients are one of the costliest quietly growing burdens in medicine. Roughly 15 to 25...

4 min read

Stroke Models Need Diversity: What Age, Sex, and Comorbidity Change About the Data

Stroke remains one of the highest attrition areas in drug development. Despite decades of preclinical programs showing...

4 min read

Biomarker Strategy in Large Animal Preclinical Studies: What Actually Translates

Biomarkers have become the connective tissue of modern drug development. They anchor mechanism of action claims,...

3 min read

Beyond Rodents: How Translational Pig Models Are De-Risking Pain Programs

The attrition rate for analgesic compounds remains stubbornly high. By some estimates, fewer than 2% of preclinical...