Peripheral Nerve Repair: What the Regeneration Endpoints Actually Tell You
Peripheral nerve repair occupies an unusual position in translational neuroscience. The biology is more permissive than in the central nervous...
preclinical drug development
Osteoarthritis Pain Models: Choosing the Species Before You Choose the Endpoint
Osteoarthritis is one of the largest unmet needs in pain, and one of the most stubborn translational problems in the field. The patient population is...
Electrophysiology as a Translational Endpoint: Why Nerve Conduction Belongs in More Preclinical Packages
Most preclinical neuroscience programs are still built around two categories of evidence. Behavior tells you what the animal does, and histology...
Quantitative Histology: What Computational Image Analysis Adds to a Preclinical Package
Histology has always carried a quiet tension. It is the most direct evidence a preclinical study can offer, a look at the actual tissue the candidate...
The Cuprizone Model: Reading Demyelination and Remyelination Without the Autoimmune Noise
Remyelination has become the most interesting frontier in multiple sclerosis. The approved therapies for relapsing disease are effective at...
BoNT in Postsurgical Pain: Mechanistic and Behavioral Findings from a Porcine SMIR Model
Botulinum toxin type A has been established as a therapeutic agent in spasticity, dystonia, and cosmetic indications for several decades. Its...
Adult Tissue and Sex Diversity in SCI: Translational Drug Development
Spinal cord injury presents one of the most challenging translational profiles in central nervous system drug development. The clinical need is...
GLP Toxicology Studies in Neuroscience
Toxicology is a defining step between exploratory research and clinical development. As programs move toward IND-enabling requirements, the need for...
Critical Endpoints in Preclinical Pain Studies: Behavioral, Biomarker, and Electrophysiology Assessments
Developing effective therapeutics for pain requires selecting endpoints that accurately reflect the biological, functional, and neurophysiological...