Neural Connections Blog

MD Biosciences insights discussing preclinical research in pain, neurodegeneration, and wound healing.

preclinical drug development (2)

Electrophysiology

Electrophysiology as a Translational Endpoint: Why Nerve Conduction Belongs in More Preclinical Packages

Most preclinical neuroscience programs are still built around two categories of evidence. Behavior tells you what the animal does, and histology...

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histology/IHC

Quantitative Histology: What Computational Image Analysis Adds to a Preclinical Package

Histology has always carried a quiet tension. It is the most direct evidence a preclinical study can offer, a look at the actual tissue the candidate...

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corpus callosum

The Cuprizone Model: Reading Demyelination and Remyelination Without the Autoimmune Noise

Remyelination has become the most interesting frontier in multiple sclerosis. The approved therapies for relapsing disease are effective at...

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skin of a representative animal that received a full-skin and muscle incision and retraction surgery (Cornet et al. 2022)

BoNT in Postsurgical Pain: Mechanistic and Behavioral Findings from a Porcine SMIR Model

Botulinum toxin type A has been established as a therapeutic agent in spasticity, dystonia, and cosmetic indications for several decades. Its...

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H&E staining of spinal cord

Adult Tissue and Sex Diversity in SCI: Translational Drug Development

Spinal cord injury presents one of the most challenging translational profiles in central nervous system drug development. The clinical need is...

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GLP Toxicology Studies in Neuroscience

Toxicology is a defining step between exploratory research and clinical development. As programs move toward IND-enabling requirements, the need for...

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Critical Endpoints in Preclinical Pain Studies: Behavioral, Biomarker, and Electrophysiology Assessments

Developing effective therapeutics for pain requires selecting endpoints that accurately reflect the biological, functional, and neurophysiological...

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MD Biosciences Signs the Marseille Declaration

MD Biosciences has signed the Marseille Declaration, the first joint pharmaceutical industry statement on animal housing and use. By signing, we...

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How Close Are We to Clinical Translation? Large-Animal Models for SCI

Spinal cord injury (SCI) remains one of the most challenging neurological conditions to treat, with few therapies successfully translating from the...

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