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Neural Connections Blog

 

4 min read

Biomarker Strategy in Large Animal Preclinical Studies: What Actually Translates

Biomarkers have become the connective tissue of modern drug development. They anchor mechanism of action claims,...

3 min read

Beyond Rodents: How Translational Pig Models Are De-Risking Pain Programs

The attrition rate for analgesic compounds remains stubbornly high. By some estimates, fewer than 2% of preclinical...

4 min read

The Göttingen Minipig in GLP Toxicology: A Practical Guide for Program Planning

Species selection for GLP toxicology is one of those decisions that quietly shapes everything downstream. It influences...

3 min read

In Vitro Is Not Enough: Why Large Animal Models Still Drive Pain Drug Approvals

The last five years have seen remarkable advances in in vitro and ex vivo pain research. Human DRG organoids,...

3 min read

From Pig Model to FDA Approval: Lessons from the ZYNRELEF Story

The gap between preclinical efficacy and clinical success in pain drug development is well-documented and widely...