Behavioral Assessments in Preclinical Models
Neurological diseases often result in a combination of motor and cognitive deficits. To gain a broader understanding of the underlying biological...
Preclinical Discovery
Animal Welfare in Preclinical Studies
Maintaining high standards of animal welfare in preclinical research is crucial for both ethical integrity and scientific reliability. Proper pig...
Acute Kidney Injury: Insights From In Vivo Biomarker Assessments
In vivo Acute Kidney Injury (AKI) models are commonly used to study renal damage and evaluate potential therapeutic interventions. Several models...
Inflammatory Pain Models in Preclinical Research
Arthritic joint pain is a hallmark of inflammatory diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). Preclinical models are...
Models of Acute Inflammatory Pain
Acute inflammatory pain is commonly associated with tissue injury and is characterized by neuronal plasticity involving both central and peripheral...
The Development of Peripheral Nerve Repair Models
Nerve damage refers to injury or impairment to the nervous system. This can lead to loss of sensation, pain, or total paralysis. Nerve repair...
Inflammatory Biomarker Detection Increases Value in Early Drug Development
Inflammation is a key pathological driver in many neurological diseases. The interplay between the central and peripheral nervous systems and the...
The HTX-011 Story
HTX-011 Breakthrough in Pain Management ZYNRELEF, the commercial name for HTX-011, is the first and only FDA-approved extended-release dual-acting...
Translating Preclinical Data to the Clinic
It's a question that comes up regularly, from scientists who contact us to publications to conference lectures. One of the challenges in preclinical...