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Neural Connections Blog

MD Biosciences insights discussing preclinical research in pain, neurodegeneration, and wound healing.

Preclinical Discovery

From Preclinical Signal to Clinical Confidence: What Pig Models Reveal That Rodents Can’t

The challenge in translational research is not generating data but generating actionable confidence.

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Why Pigs Are Becoming the Preferred Large Animal Model in Pain and Wound Healing Research

Pain and wound healing research demand models that accurately reflect human tissue structure, innervation, and functional recovery. While rodents...

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When Rodents Aren’t Enough: How Translational Pig Models Reduce Late-Stage Risk

Drug development rarely fails because a compound lacked activity. More often, it fails because preclinical models failed to predict clinical reality.

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GLP Toxicology Studies in Neuroscience

Toxicology is a defining step between exploratory research and clinical development. As programs move toward IND-enabling requirements, the need for...

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Uncovering Early Signals of Disease in EAE Models with EP

Experimental autoimmune encephalomyelitis (EAE) is one of the most widely used and well-characterized models for studying multiple sclerosis (MS)....

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Critical Endpoints in Preclinical Pain Studies: Behavioral, Biomarker, and Electrophysiology Assessments

Developing effective therapeutics for pain requires selecting endpoints that accurately reflect the biological, functional, and neurophysiological...

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Use of a Porcine Model for Studying Spinal Cord Injury

At this year’s Society for Neuroscience (SfN) meeting, our team presented a poster highlighting the advantages of using a porcine model to bridge the...

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A Closer Look at Neuroma in Pigs and Sex-Specific Pain Responses

At the forefront of translational large-animal research, our team has developed clinically relevant pig models to study nerve injury and pain....

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International Congress on Neuropathic Pain 2025

We had the opportunity to present at NeuPSIG 2025 in Berlin, sharing our latest findings in neuropathic pain research. The conference offered...

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