Adult Tissue and Sex Diversity in SCI: Translational Drug Development
Spinal cord injury presents one of the most challenging translational profiles in central nervous system drug development. The clinical need is...
Preclinical Discovery (2)
Type 2 Diabetic Neuropathy in the GLP-1 Era
GLP-1 receptor agonists have substantially reshaped the therapeutic landscape for type 2 diabetes and obesity, and the indications now being pursued...
Rethinking the Preclinical Package for Chronic Kidney Disease: Why Pigs belong in the conversation
Drug development for chronic kidney disease has entered a more ambitious phase. SGLT2 inhibitors, non steroidal mineralocorticoid receptor...
From Preclinical Signal to Clinical Confidence: What Pig Models Reveal That Rodents Can’t
The challenge in translational research is not generating data but generating actionable confidence.
Why Pigs Are Becoming the Preferred Large Animal Model in Pain and Wound Healing Research
Pain and wound healing research demand models that accurately reflect human tissue structure, innervation, and functional recovery. While rodents...
When Rodents Aren’t Enough: How Translational Pig Models Reduce Late-Stage Risk
Drug development rarely fails because a compound lacked activity. More often, it fails because preclinical models failed to predict clinical reality.
GLP Toxicology Studies in Neuroscience
Toxicology is a defining step between exploratory research and clinical development. As programs move toward IND-enabling requirements, the need for...
Uncovering Early Signals of Disease in EAE Models with EP
Experimental autoimmune encephalomyelitis (EAE) is one of the most widely used and well-characterized models for studying multiple sclerosis (MS)....
Critical Endpoints in Preclinical Pain Studies: Behavioral, Biomarker, and Electrophysiology Assessments
Developing effective therapeutics for pain requires selecting endpoints that accurately reflect the biological, functional, and neurophysiological...