From Preclinical Signal to Clinical Confidence: What Pig Models Reveal That Rodents Can’t
The challenge in translational research is not generating data but generating actionable confidence.
Pain
Why Pigs Are Becoming the Preferred Large Animal Model in Pain and Wound Healing Research
Pain and wound healing research demand models that accurately reflect human tissue structure, innervation, and functional recovery. While rodents...
When Rodents Aren’t Enough: How Translational Pig Models Reduce Late-Stage Risk
Drug development rarely fails because a compound lacked activity. More often, it fails because preclinical models failed to predict clinical reality.
Critical Endpoints in Preclinical Pain Studies: Behavioral, Biomarker, and Electrophysiology Assessments
Developing effective therapeutics for pain requires selecting endpoints that accurately reflect the biological, functional, and neurophysiological...
A Closer Look at Neuroma in Pigs and Sex-Specific Pain Responses
At the forefront of translational large-animal research, our team has developed clinically relevant pig models to study nerve injury and pain....
Behavioral Assessments in Preclinical Pain Models
Chronic pain affects 1 in 5 adults in the US, making it one of the most common chronic conditions 1. Approved analgesics often lack efficacy and have...
New Developments: Innovative Cold Pain Testing Methods
Cold testing in rats serves as a crucial tool in pain research, particularly in studying neuropathic pain and assessing the effectiveness of drugs....
Models of Acute Inflammatory Pain
Acute inflammatory pain is commonly associated with tissue injury and is characterized by neuronal plasticity involving both central and peripheral...
The Development of Peripheral Nerve Repair Models
Nerve damage refers to injury or impairment to the nervous system. This can lead to loss of sensation, pain, or total paralysis. Nerve repair...