From Acute to Chronic: Where the 2026 Sodium Channel Programs Are Headed
As of August 2026, acute post-surgical pain has an approved non-opioid sodium channel blocker and a second program with published Phase 2b data....
Electrophysiology
Peripheral Nerve Repair: What the Regeneration Endpoints Actually Tell You
Peripheral nerve repair occupies an unusual position in translational neuroscience. The biology is more permissive than in the central nervous...
Electrophysiology as a Translational Endpoint: Why Nerve Conduction Belongs in More Preclinical Packages
Most preclinical neuroscience programs are still built around two categories of evidence. Behavior tells you what the animal does, and histology...
Uncovering Early Signals of Disease in EAE Models with EP
Experimental autoimmune encephalomyelitis (EAE) is one of the most widely used and well-characterized models for studying multiple sclerosis (MS)....
Critical Endpoints in Preclinical Pain Studies: Behavioral, Biomarker, and Electrophysiology Assessments
Developing effective therapeutics for pain requires selecting endpoints that accurately reflect the biological, functional, and neurophysiological...
The Critical Role of Clinical Relevance in Effective Study Design
Enhancing clinical relevance in early-stage studies can improve efficiency, reduce costs, and guide critical decisions, ultimately advancing more CNS...
The Development of Peripheral Nerve Repair Models
Nerve damage refers to injury or impairment to the nervous system. This can lead to loss of sensation, pain, or total paralysis. Nerve repair...
New Publication - A novel sensory wave (p25) in MOG-EAE model
MD Biosciences has published a new article in the Journal of Pain describing a novel sensory wave (P25) in the MOG-induced EAE model. This article...
Do clinical scores tell us all we need to know?
Multiple sclerosis is a disease in which the immune system attacks the myelin sheath that covers nerve fibers. People suffering from this autoimmune...