Uncovering Early Signals of Disease in EAE Models with EP
Experimental autoimmune encephalomyelitis (EAE) is one of the most widely used and well-characterized models for studying multiple sclerosis (MS)....
Electrophysiology
Critical Endpoints in Preclinical Pain Studies: Behavioral, Biomarker, and Electrophysiology Assessments
Developing effective therapeutics for pain requires selecting endpoints that accurately reflect the biological, functional, and neurophysiological...
The Critical Role of Clinical Relevance in Effective Study Design
Enhancing clinical relevance in early-stage studies can improve efficiency, reduce costs, and guide critical decisions, ultimately advancing more CNS...
The Development of Peripheral Nerve Repair Models
Nerve damage refers to injury or impairment to the nervous system. This can lead to loss of sensation, pain, or total paralysis. Nerve repair...
New Publication - A novel sensory wave (p25) in MOG-EAE model
MD Biosciences has published a new article in the Journal of Pain describing a novel sensory wave (P25) in the MOG-induced EAE model. This article...
Do clinical scores tell us all we need to know?
Multiple sclerosis is a disease in which the immune system attacks the myelin sheath that covers nerve fibers. People suffering from this autoimmune...
What electrophysiology brings to preclinical studies
Neurons communicate with each other as well as other muscles and organs through electrical events called action potentials and neurochemical...
Monitoring pain in EAE animals experiencing paralysis
Many neurodegenerative diseases such as Multiple Sclerosis, ALS, and Rhett Syndrome involve paralysis. When developing new treatments, it is...