Sciatic Nerve Crush
Peripheral Nerve Injury Model of Neuropathic Pain
Assessment of Nerve Regeneration
Neuropathic pain may arise from many different disease states and present with a variety of symptoms, including shooting or burning pain, tingling, numbness, and allodynia, Clinically significant relief is often difficult to achieve, in part because conventional opioid therapy is typically less effective for neuropathic pain. Understanding the mechanisms and underlying neuropathic pain syndromes is crucial to the development of more effective therapies.
- Species: Mouse or Rat
- Model length: up to 31 days
- Positive controls: morphine, gabapentin, pregabalin
- Readouts: tactile allodynia, cold allodynia
- Endpoints: histology, biomarker analysis (protein or mRNA levels)
Pain response using Von Frey in the nerve crush model.