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Sciatic Nerve Crush

Peripheral Nerve Injury Model of Neuropathic Pain

Assessment of Nerve Regeneration


Neuropathic pain may arise from many different disease states and present with a variety of symptoms, including shooting or burning pain, tingling, numbness, and allodynia, Clinically significant relief is often difficult to achieve, in part because conventional opioid therapy is typically less effective for neuropathic pain. Understanding the mechanisms and underlying neuropathic pain syndromes is crucial to the development of more effective therapies.


Model Specifications

  • Species: Mouse or Rat
  • Model length: up to 31 days
  • Positive controls: morphine, gabapentin, pregabalin
  • Readouts: tactile allodynia, cold allodynia
  • Endpoints: histology, biomarker analysis (protein or mRNA levels)


Von Frey

Pain response using Von Frey in the nerve crush model. 



If you are ready to discuss how a partnership can fit into your development program, our scientists are eager to explore the possibilities with you. Like many other pharmaceutical and medical device developers, you can rely on predictive preclinical data.

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