Neural Connections Blog

MD Biosciences insights discussing preclinical research in pain, neurodegeneration, and wound healing.

translational research

AAALAC accreditation

What AAALAC Accreditation Actually Signals to Partners

AAALAC accreditation carries practical weight in preclinical drug development, and its implications for program quality extend beyond the credential...

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skin of a representative animal that received a full-skin and muscle incision and retraction surgery (Cornet et al. 2022)

BoNT in Postsurgical Pain: Mechanistic and Behavioral Findings from a Porcine SMIR Model

Botulinum toxin type A has been established as a therapeutic agent in spasticity, dystonia, and cosmetic indications for several decades. Its...

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H&E staining of spinal cord

Adult Tissue and Sex Diversity in SCI: Translational Drug Development

Spinal cord injury presents one of the most challenging translational profiles in central nervous system drug development. The clinical need is...

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Paw withdrawal in the ZDF model

Type 2 Diabetic Neuropathy in the GLP-1 Era

GLP-1 receptor agonists have substantially reshaped the therapeutic landscape for type 2 diabetes and obesity, and the indications now being pursued...

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Rethinking the Preclinical Package for Chronic Kidney Disease: Why Pigs belong in the conversation

Drug development for chronic kidney disease has entered a more ambitious phase. SGLT2 inhibitors, non steroidal mineralocorticoid receptor...

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From Preclinical Signal to Clinical Confidence: What Pig Models Reveal That Rodents Can’t

The challenge in translational research is not generating data but generating actionable confidence.

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Why Pigs Are Becoming the Preferred Large Animal Model in Pain and Wound Healing Research

Pain and wound healing research demand models that accurately reflect human tissue structure, innervation, and functional recovery. While rodents...

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Use of a Porcine Model for Studying Spinal Cord Injury

At this year’s Society for Neuroscience (SfN) meeting, our team presented a poster highlighting the advantages of using a porcine model to bridge the...

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A Closer Look at Neuroma in Pigs and Sex-Specific Pain Responses

At the forefront of translational large-animal research, our team has developed clinically relevant pig models to study nerve injury and pain....

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