Neural Connections Blog

MD Biosciences insights discussing preclinical research in pain, neurodegeneration, and wound healing.

pig

From Acute to Chronic: Where the 2026 Sodium Channel Programs Are Headed

As of August 2026, acute post-surgical pain has an approved non-opioid sodium channel blocker and a second program with published Phase 2b data....

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Rethinking the Preclinical Package for Chronic Kidney Disease: Why Pigs belong in the conversation

Drug development for chronic kidney disease has entered a more ambitious phase. SGLT2 inhibitors, non steroidal mineralocorticoid receptor...

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From Preclinical Signal to Clinical Confidence: What Pig Models Reveal That Rodents Can’t

The challenge in translational research is not generating data but generating actionable confidence.

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Why Pigs Are Becoming the Preferred Large Animal Model in Pain and Wound Healing Research

Pain and wound healing research demand models that accurately reflect human tissue structure, innervation, and functional recovery. While rodents...

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When Rodents Aren’t Enough: How Translational Pig Models Reduce Late-Stage Risk

Drug development rarely fails because a compound lacked activity. More often, it fails because preclinical models failed to predict clinical reality.

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