Beyond Rodents: How Translational Pig Models Are De-Risking Pain Programs
The attrition rate for analgesic compounds remains stubbornly high. By some estimates, fewer than 2% of preclinical pain candidates reach approval, a...
The Göttingen Minipig in GLP Toxicology: A Practical Guide for Program Planning
Species selection for GLP toxicology is one of those decisions that quietly shapes everything downstream. It influences study timelines, regulatory...
In Vitro Is Not Enough: Why Large Animal Models Still Drive Pain Drug Approvals
The last five years have seen remarkable advances in in vitro and ex vivo pain research. Human DRG organoids, iPSC-derived sensory neurons,...
From Pig Model to FDA Approval: Lessons from the ZYNRELEF Story
The gap between preclinical efficacy and clinical success in pain drug development is well-documented and widely lamented. Fewer than 2% of analgesic...
Choosing Your Preclinical Species: How Rodents, Dogs, NHPs, and Pigs Compare in Pain Research
Every preclinical pain program begins with a species decision, which shapes everything downstream, including endpoint selection, translational...
Sex Differences in Pain Research: What Your Preclinical Program May Be Missing
In 2016, the NIH mandate on sex as a biological variable (SABV) formalized what pain researchers had known for years: males and females process pain...
The NaV1.8 Era: What Journavx Means for Pain Drug Development
For the first time in over two decades, the FDA has approved a new class of pain medication. Vertex Pharmaceuticals' suzetrigine (Journavx), a...
From Preclinical Signal to Clinical Confidence: What Pig Models Reveal That Rodents Can’t
The challenge in translational research is not generating data but generating actionable confidence.
Modeling diabetic neuropathy with mechanistic and translational considerations
Diabetic neuropathy affects nearly half of individuals living with diabetes, yet its underlying biological drivers remain only partially defined....