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Translational Models of Post-Operative Pain

Increasing the predictability of your preclinical studies by using models that are relevant to the clinical situation.


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Post-operative Pain in Pigs for translational studies


Rodents have been the model of choice for the development of new treatments for acute pain, however, several limitations exist. Rodents are not useful for assessing topical and localized treatments, the anatomy of the skin differs from human skin, and healing occurs by wound contraction. Since pigs share similarities with human skin and heal by epidermal cell migration, MD Biosciences Neuro has characterized multiple porcine models for post-operative pain (POP).


Pig POP Models

We've discussed the benefits of the pig as a translational model. Specifically in the POP model, programs benefit in the following ways:

  • Reproducibility 
  • Mimics human condition
  • Monitoring of PK/PD 
  • Routes and volumes of administration relevant to humans 
  • Understanding of safety/PD/PK using the same animals

MD Biosciences has validated and published several pig models for post-operative pain: 


Example Data

In a study, we aimed to evaluate the effect of Marcain and Exparel in the pig POP model. In additional to traditional pain assessments, we evaluate the locomotor activity of the animals. Data show open field post application in the pig POP model. 



Open Field Pig POP


If you are ready to discuss how translational studies can fit into your development program, our scientists are eager to explore the possibilities with you. Like many other pharmaceutical and medical device developers, you can rely on predictive preclinical data.  

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