Post-operative Pain in Pigs for translational studies
Rodents have been the model of choice for the development of new treatments for acute pain, however, several limitations exist. Rodents are not useful for assessing topical and localized treatments, the anatomy of the skin differs from human skin, and healing occurs by wound contraction. Since pigs share similarities with human skin and heal by epidermal cell migration, MD Biosciences Neuro has characterized multiple porcine models for post-operative pain (POP).
Pig POP Models
We've discussed the benefits of the pig as a translational model. Specifically in the POP model, programs benefit in the following ways:
- Mimics human condition
- Monitoring of PK/PD
- Routes and volumes of administration relevant to humans
- Understanding of safety/PD/PK using the same animals
MD Biosciences has validated and published several pig models for post-operative pain:
In a study, we aimed to evaluate the effect of Marcain and Exparel in the pig POP model. In additional to traditional pain assessments, we evaluate the locomotor activity of the animals. Data show open field post application in the pig POP model.