Efficacy studies for pain are run in mostly male subjects. Could that be contributing to clinical stage failures of active compounds?
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In this webinar, we present data from a post-operative pain model that suggests the nerve fiber density and pain response between male and females is different. In fact, morphine has a different effect on males than females. This leads to the question of whether sex differences could be contributing to the failure rate of therapeutic candidates reaching late clinical stages.
Webinar (25 min)