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Neuroscience Laboratory Services

Porcine Neuropathic Pain

A clinically-relevant model of neuropathic pain in pigs

Pig Model of Neuropathic Pain

 

While rodent models of neuropathic pain have provided value in the research community, translational models in the pig can offer a higher degree of clinical relevance, which is why we also offer such models. 

 

 

Advantages (range from technical to scientific)

  • Volume of injection, nerve stimulation, imaging, PK, behavioral changes, skin biomarkers. 
  • System similarities between the pig and human including the cardiovascular, central nervous, immune and digestive systems.
  • Correlation between contracile, metabolic and morphological features in skeletal muscle of humans and pigs.
  • Pigs exhibit a higher degree of homology to human skin than murine skin, making the pig a preferable animal model for wound healing studies involving transdermal drug delivery. 

 

Available Assessments 

  • von Frey
  • Motor Function
  • Spontaneous Behavior
  • Biomarkers
  • Histology/IHC
  • PK

von Frey

von frey in the neuritis neuropathy due to sciatic nerve injury in the pigs

                                   Morphine was administered at 1 mg/kg intramuscularly on day 28.                                                                       von Frey was measured and Morphine reversed the response by                                                                           nearly 50% compared to untreated animals. 

 

Request Study Proposal

 

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Main Fax: 1-888-876-3246

Neuro Lab: +972 (8) 939 6884 


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