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MBP-induced EAE

A self-remitting efficacy model for the study of Multiple Sclerosis

 

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Self-remitting myelin basic protein (MBP) induced EAE Efficacy Model for Multiple Sclerosis (MS)

 

When conducting MS research,  administration of one dose of MBP in a Lewis rat leads to a single relapse that is characterized by hind paw paralysis. This can be characterized histologically, by infiltration of mononuclear cells to the cervical spinal cord and formation of foci. This model is self-limiting and does not show demyelination.

Assessments

MD Biosciences incorporates a range of in vivo measures and endpoint assessments that provide a robust data package that enable researchers to make critical decisions. 

 
Pain behavioral anaysis

Behavior 

Pain behavior tests include dynamic weightbearing and Hargreaves to assess the distribution on each paw and sensitivity to heat.  
biomarker

Biomarkers

Evaluate pro-inflammatory and anti-inflammatory biomarkers from CSF samples. 
histology

Histology

IHC and histological staining to evaluate inflammatory markers in the paw skin. 

Scientific Data

H&E staining of brain tissue for detection of inflammatory cells infiltrating into the spinal cord.

 
MBP-Induced-EAE-H&E-Staining-Brain-Tissue-Spinal-Cord
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EAE datasheet

 

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READY TO DISCUSS YOUR PROGRAM?

If you are ready to discuss how a partnership can fit into your development program, our scientists are eager to explore the possibilities with you. Like many other pharmaceutical and medical device developers, you can rely on predictive preclinical data.

 

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