Self-remitting myelin basic protein (MBP) induced EAE Efficacy Model for Multiple Sclerosis (MS)
When conducting MS research, administration of one dose of MBP in a Lewis rat leads to a single relapse that is characterized by hind paw paralysis. This can be characterized histologically, by infiltration of mononuclear cells to the cervical spinal cord and formation of foci. This model is self-limiting and does not show demyelination.
H&E staining of brain tissue for detection of inflammatory cells infiltrating into the spinal cord.