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Cuprizone Model of Demyelination and Remyelination
Cuprizone drives reproducible oligodendrocyte loss and demyelination in defined brain regions. Continued exposure sustains demyelination, while withdrawal allows spontaneous remyelination, giving a controlled window to assess both myelin loss and repair. At MD Biosciences, demyelination is induced in C57BL/6 mice and quantified by MBP histology, including optical density and corpus callosum thickness.
