We had the opportunity to present at NeuPSIG 2025 in Berlin, sharing our latest findings in neuropathic pain research. The conference offered valuable discussions and collaborative learning across the pain research community.
Learn more about the topics we presented below:
Analysis of Regenerative Peripheral Nerve Interface Procedure with Neuroma Retention versus Neuroma Excision in a Distal Tibial Injury Rat Model
The Regenerative Peripheral Nerve Interface (RPNI) is an innovative technique designed to prevent neuroma formation and promote nerve regeneration by inserting the severed nerve end into a muscle graft. While RPNI has shown promise in improving nerve regeneration, there is ongoing debate about whether neuromas should be retained or excised during the procedure. This study aimed to assess the outcomes of RPNI with neuroma retention versus excision using a distal tibial injury rat model, with a focus on functional recovery, histology, and pain assessment. Download the poster here. VEP and ERG Monitoring in STZ-Induced Peripheral Neuropathy in Rats:
VEP and ERG provide a comprehensive evaluation of the visual system in diabetic patients, from the retina to the visual cortex, enabling detection and monitoring of disease progression, and assessment of intervention effectiveness. These tools offer valuable insights for managing diabetic complications and potentially improving patient outcomes. In this study we show for the first time changes in VEP and ERG in STZ induced diabetes in mice. We also correlated those changes with the traditional measurements of tactile allodynia and blood flow.
Characterization of a New Peripheral Painful Neuroma Model in Göttingen Minipigs
Göttingen Minipigs (GMP) were selected due to their physiological similarity to humans in terms of peripheral nerve structure, function, and repair, their acceptability in toxicological studies, and their suitability for long-term follow-up due to slower growth rates. The pig neuroma model closely resembles the human condition, particularly in that not all animals develop pain—mirroring the variability observed in humans. The anatomical size of pigs allows for the creation of critical nerve gaps ranging from 4–7 cm, and even exceeding 7 cm.
This study examined cisplatin-induced neurodegeneration in vitro and associated changes in pain behavior in vivo and paclitaxel (Taxol) effects on mitochondrial trafficking in DRG cells in vitro along with acetylated alpha tubulin levels in the DRG of Taxol-exposed rats. Download the poster here.
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