RealBrain^® Models

MD Biosciences is pleased to introduce RealBrain® technology through an exclusive partnership with Tessara Therapeutics.  

Tessara Therapeutics has developed a unique cell-based platform, RealBrain®, which models neural micro-tissues for drug discovery. Together, MD Biosciences and Tessara Therapeutics have joined forces in introducing this technology to a broader user base.

RealBrain^® Functionality

RealBrain® provides high modeling accuracy of traditional organoids, but with far greater ease of production, reproducibility and optical clarity. These 3D models capture the complexity of the human brain by differentiating neural stem cells in an advanced chemically-defined polymer matrix that are compatible with 96 or 384-well plate formats. The RealBrain® Matrix is an ideal micro-environment for developing a mature heterogenous cell population that demonstrates neural functionality and differentiation in just 3 weeks. The cell population exhibits synaptic maturity, neurotransmitter responsiveness, and voltage gated ion channels.

Benefits include:

• Biological accuracy: mature models feature a heterogeneous 3D mix of neural cell types
• Fully human: models are derived from primary human and iPS-derived neural stem cells
• Optical quality: models are clear with optimal cell density for high-content imaging
• Scalable and reproducible: automated production generates highly consistent models
• Compatible: micro-tissues can be incorporated into all standard 96-well assays
• Disease ready: Models of both normal brain and Alzheimer’s disease
• Short timeline of only 3 weeks to study-ready cells.

READY TO DISCUSS YOUR PROGRAM?

If you are ready to discuss how a partnership can fit into your development program, our scientists are eager to explore the possibilities with you. Like many other pharmaceutical and medical device developers, you can rely on predictive preclinical data.